To explore and to discover more in-depth on the mechanism of botanical extract, we have invested time on scientific studies by taking advantages of collaborations with medical and laboratories with high esteem and great achievements in Taiwan. We have built strong partnership with experts and scientists from Medical Center of National Taiwan University(NTU), Taipei Medical University Hospital(TMUH), National Health and Research Institute(NHRI), and Hong Kong University(HKU). The subjects of our scientific studies are listed as follow:

Scientific studies on Botanical Extract

1. Immunomodulating effect of Chinese herbal mixture on peripheral blood mononuclear cells and T-lymphocytes. (NTU , March 2000~Feb 2001)

2. Induction of apoptosis in K562, U937, MT-2, CT26/RT1 cancer cell lines by Chinese herbal mixture. (NTU, March 2000~Feb 2001)

3. Inhibition of cell growth and induction of apoptosis in 15 human cancer cell lines by Chinese herbal mixture. (NTU, Nov 2001~ Oct 2002)

4. Inhibition of cell growth and induction of apoptosis in a variety of cancer cell lines by Chinese herbal mixture. (NTU, Nov 2002~ June 2004)

5. A Pilot study to Evaluate the Effect of Chinese Botanical Extract on the Immunity of Cancer Patients receiving radiation therapy. (TMUH, Aug 2003~ July 2004)

6. The study of Suppression of Adenocarcinoma cell 755 in vivo by Botanical Extract. (Hokaido New Drug Development Center, Japan, Feb 2004~Sep 2004)

7. Stimulation of anti-tumor T-cell activity and inhibition of tumor metastasis by Chinese Botanical Extract. (NTU, April 2005~March 2006)

8. Inhibition of angiogenesis induced by cancer cells by Chinese Botanical Extract. (NTU, April 2005~ March 2007)

9. Botanical Extract and Its Active Fraction Induced Degradation of PML-RARα Fusion Protein and Suppressed Oncogenic Signaling Pathways in Human Acute Promyelocytic Leukemia NB4 Cells. (NHRI, Jan 2006~Dec 2006)

10. Botanical Extract and Its Active Fraction induces G2/M Arrest and Apoptosis in Human Acute Promyelocytic Leukemia NB4 Cells. (NHRI, Jan 2006~Dec 2006)

11. Elimination of Cancer Stem-like Cells by Botanical Extract and Its Active Fraction. (NHRI, Jan 2006~Dec 2006)

12. Botanical Extract and Its Active Fraction Inhibits Growth of MCF-7 Breast Cancer Cells Accompanied with Down Regulation of DNA Methyltransferase 1 Expression and the Phosphorylation of Akt/PKB (NHRI, Jan 2007~ Dec 2007)

13. Botanical Extract and Its Active Fraction -mediated Iinhibition of Rad51 Repair Enzyme and Enhancement of Human Breast Cancer Cells Radiosensitivity. (NHRI, Jan 2007~Dec 2007)

14. Activation of PPAR-γ by Botanical Extract and Its Active Fraction. (NHRI, Jan 2007~Dec 2007)

15. Activation of AMP-dependent Kinase by Botanical Extract and Its Active Fraction. (NHRI, Jan 2007~April 2008)

16. Pre-clinical Evaluation of Botanical Extract on Cancer Therapy Monitored by Molecular Imaging. (TMU, Jan 2007~April 2008)

17. Anti-proliferation, Anti-Angiogenesis and Reversion of Multidrug-Resistance of Botanical Extract in Treatment of Colon Cancer in vivo and in vitro. (HKU, Feb 2008~ Jan 2009)

18. Inhibition of the growth of MDA-MB-231 human cancer cells in SCID mice by Chinese Botanical Extract. (NTU, July 2008~ Feb 2009)